解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Many prior studies have shown that, in critically ill patients, acute kidney injury (AKI) commonly occurs in association with sepsis and its presence portends an increased likelihood of poor outcomes. In contrast, few studies have focused specifically on the influence of AKI on the long-term risk of developing sepsis....
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13708
更新日期:2014-01-24 00:00:00
abstract:INTRODUCTION:Transthoracic echocardiography (TTE) is a useful tool for minimally invasive hemodynamic monitoring in the ICU. Dynamic indices (such as the inferior vena cava distensibility index (dIVC)) can be used to predict fluid responsiveness in mechanically ventilated patients. Although quantitative use of the dIVC...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13693
更新日期:2014-01-14 00:00:00
abstract::Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant o...
journal_title:Critical care (London, England)
pub_type: 信件,评审
doi:10.1186/cc13177
更新日期:2014-01-06 00:00:00
abstract::Acute kidney injury (AKI) research in the past decade has mostly focused upon development of a standard AKI definition, validation of early novel biomarkers to predict AKI prior to serum creatinine rise and predict AKI severity, and assessment of aspects of renal replacement therapies and their impact on survival. Giv...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13180
更新日期:2014-01-06 00:00:00
abstract:INTRODUCTION:A major pathophysiologic mechanism in sepsis is impaired host immunity which results in failure to eradicate invading pathogens and increased susceptibility to secondary infections. Although many immunosuppressive mechanisms exist, increased expression of the inhibitory receptor programmed cell death 1 (PD...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13176
更新日期:2014-01-04 00:00:00
abstract::Barriers to the use of selective digestive decontamination include concerns about emergence of resistant organisms, over-estimation of current performance in preventing ventilator-associated pneumonia (VAP), alternative methods of preventing VAP, and misunderstanding of mechanisms of action. A definitive cluster-rando...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13165
更新日期:2013-12-19 00:00:00
abstract:INTRODUCTION:Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-mobility group box 1 (HMGB1). In the current study we sought to determine the functional role o...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13162
更新日期:2013-12-16 00:00:00
abstract:INTRODUCTION:Abdominal distension is common in critical illness. There is a growing recognition that intra-abdominal hypertension (IAH) may complicate nonsurgical critical illness as well as after abdominal surgery. However, the pathophysiological basis of the injury to the intestinal mucosal barrier and its influence ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13146
更新日期:2013-12-09 00:00:00
abstract::In an effort to reduce the complications related to invasive ventilation, the use of noninvasive ventilation (NIV) has increased over the last years in patients with acute respiratory failure. However, failure rates for NIV remain high in specific patient categories. Several studies have identified factors that contri...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13141
更新日期:2013-12-05 00:00:00
abstract::Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly limitless maintenance of life, the exact time of death of an individual patient is often determined by the dec...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13140
更新日期:2013-12-04 00:00:00
abstract::Diagnosis of sepsis is complicated by non-specific clinical definitions and delays in laboratory analysis using tests which may have very poor predictive values. The use of host biomarker signature sets, which when measured in combination have high predictive values, offers a paradigm shift forwards for rapid, near-pa...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13137
更新日期:2013-12-04 00:00:00
abstract:INTRODUCTION:The aim of this study was to determine whether using pharmacodynamic-based dosing of antimicrobials, such as extended/continuous infusions, in critically ill patients is associated with improved outcomes as compared with traditional dosing methods. METHODS:We searched Medline, HealthStar, EMBASE, Cochrane...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc13134
更新日期:2013-11-29 00:00:00
abstract::Facilitation of early spontaneous breathing activity is the most important measure to shorten weaning and avoid ventilator-induced lung injury and diaphragmatic injury in mechanically ventilated patients. However, the optimal degree of spontaneous muscle activity and ventilator support remains to be determined. Furthe...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13120
更新日期:2013-11-19 00:00:00
abstract:INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13080
更新日期:2013-10-24 00:00:00
abstract::Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despit...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13065
更新日期:2013-10-16 00:00:00
abstract::During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small studies have demonstrated the beneficial effect of intensivists on outcomes in the cri...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13060
更新日期:2013-10-14 00:00:00
abstract:INTRODUCTION:The pathophysiology of acute kidney injury (AKI) in sepsis is ill defined. We investigated parameters associated with low glomerular filtration, and their predictive value to discriminate transient from intrinsic septic AKI. METHODS:In 107 sepsis patients, AKI was defined by the Risk, Injury, Failure, Los...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13057
更新日期:2013-10-13 00:00:00
abstract:INTRODUCTION:Impaired skeletal muscle function has important clinical outcome implications for survivors of critical illness. Previous studies employing volitional manual muscle testing for diagnosing intensive care unit-acquired weakness (ICU-AW) during the early stages of critical illness have only provided limited d...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13052
更新日期:2013-10-10 00:00:00
abstract:INTRODUCTION:Admission blood glucose (BG) level is a predictor of mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, limited data are available relating admission BG to mortality in patients with STEMI complicated by cardiogenic shock, and it is not known whether diabetic status has...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc13035
更新日期:2013-10-03 00:00:00
abstract:INTRODUCTION:Economic evaluations of interventions in the hospital setting often rely on the estimated long-term impact on patient survival. Estimates of mortality rates and long-term outcomes among patients discharged alive from the intensive care unit (ICU) are lacking from lower- and middle-income countries. This st...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13036
更新日期:2013-10-03 00:00:00
abstract:INTRODUCTION:Epidemiologic assessment of critically ill people in Intensive Care Units (ICUs) is needed to ensure the health care system can meet current and future needs. However, few such studies have been published. METHODS:Population-based analysis of all adult ICU care in the Canadian province of Manitoba, 1999 t...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc13026
更新日期:2013-09-30 00:00:00
abstract:INTRODUCTION:Inflammation and coagulation are closely linked, and both can be triggered by endotoxin. Thrombelastometry and impedance aggregometry are of diagnostic and predictive value in critically ill patients. In this observational study we investigated the correlation of endotoxin activity with thrombelasometric a...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12892
更新日期:2013-09-11 00:00:00
abstract:INTRODUCTION:This prospective study aimed to assess whether use of the subxiphoid acoustic window in transthoracic echocardiography (TTE) can be an accurate alternative in the absence of an apical view to assess hemodynamic parameters. METHODS:This prospective study took place in a teaching hospital medical ICU. Over ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12869
更新日期:2013-09-03 00:00:00
abstract::Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known a...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc12700
更新日期:2013-08-27 00:00:00
abstract:INTRODUCTION:Leukocyte infiltration is central to the development of acute lung injury, but it is not known how mechanical ventilation strategy alters the distribution or activation of inflammatory cells. We explored how protective (vs. injurious) ventilation alters the magnitude and distribution of lung leukocyte acti...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12854
更新日期:2013-08-15 00:00:00
abstract:INTRODUCTION:Sepsis, severe sepsis and septic shock are common conditions with high mortality. Their early diagnosis in the Emergency Department (ED) is one of the keys to improving survival. Procalcitonin (PCT) has been used as a biomarker in septic patients but has limited specificity and can be elevated in other sce...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc12847
更新日期:2013-07-30 00:00:00
abstract:INTRODUCTION:This systematic review looks at the use of noninvasive ventilation (NIV), inclusive of noninvasive positive pressure ventilation (NPPV) and continuous positive pressure ventilation (CPAP), in patients with chest trauma to determine its safety and clinical efficacy in patients with blunt chest trauma who ar...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc12821
更新日期:2013-07-22 00:00:00
abstract:INTRODUCTION:Contrast-enhanced ultrasound (CEUS) is a new technique that might enable portable and non-invasive organ perfusion quantification at the bedside. However, it has not yet been tested in critically ill patients. We sought to establish CEUS's feasibility, safety, reproducibility and potential diagnostic value...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12817
更新日期:2013-07-12 00:00:00
abstract:INTRODUCTION:A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU). METHODS:An IRB-approved prospective observational study was conducted from January 24, 2010, to ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12807
更新日期:2013-07-04 00:00:00
abstract::Glucocorticoid use in sepsis is controversial. In contrast to other extracellular signaling molecules, glucocorticoid receptors (GRs) are intra-cytoplasmic. Several GR isoforms have been identified. A study in Critical Care Forum suggests that sepsis alters the abundance of the dominant negative GRβ. Here we discuss G...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc12723
更新日期:2013-06-27 00:00:00
abstract::Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection. While inhibiti...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc12722
更新日期:2013-06-11 00:00:00
abstract:INTRODUCTION:Diclofenac, a nonsteroidal antiinflammatory drug, is commonly used as antipyretic therapy in intensive care. The purpose of this study was to investigate the effects of parenteral diclofenac infusion on brain homeostasis, including brain-tissue oxygen tension (PbtO2) and brain metabolism after aneurysmal s...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12714
更新日期:2013-05-12 00:00:00
abstract::Urinary indices are classically believed to allow differentiation of transient (or pre-renal) acute kidney injury (AKI) from persistent (or acute tubular necrosis) AKI. However, the data validating urinalysis in critically ill patients are weak. In the previous issue of Critical Care, Pons and colleagues demonstrate i...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12676
更新日期:2013-05-07 00:00:00
abstract:INTRODUCTION:To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS:Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. Al...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc12598
更新日期:2013-04-25 00:00:00
abstract::Perioperative hemodynamic optimization, or goal-directed therapy (GDT), has been show to significantly decrease complications and risk of death in high-risk patients undergoing noncardiac surgery. An important aim of GDT is to prevent an imbalance between oxygen delivery and oxygen consumption in order to avoid the de...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc11861
更新日期:2013-03-19 00:00:00
abstract::Base deficit has frequently been utilized as an informal adjunct in the initial evaluation of trauma patients to assess the extent of their physiologic derangements. However, the current Advanced Trauma Life Support (ATLS) classification system for hypovolemic shock does not include base-deficit measurements and relie...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc12513
更新日期:2013-03-13 00:00:00
abstract:INTRODUCTION:Improved methods to optimize drug dosing in the critically ill are urgently needed. Traditional prescribing culture involves recognition of factors that mandate dose reduction (such as renal impairment), although optimizing drug exposure, through more frequent or augmented dosing, represents an evolving st...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12544
更新日期:2013-02-28 00:00:00
abstract:INTRODUCTION:Critically ill cirrhosis patients awaiting liver transplantation (LT) often receive prioritization for organ allocation. Identification of patients most likely to benefit is essential. The purpose of this study was to examine whether the Sequential Organ Failure Assessment (SOFA) score can predict 90-day m...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc12508
更新日期:2013-02-09 00:00:00
abstract::Large numbers of patients who survive critical illness are left with significant new cognitive impairments that are often severe and remain years after hospital discharge. In the previous issue of Critical Care, Guerra and colleagues assessed risk factors for the development of dementia after an intensive care unit (I...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11913
更新日期:2013-02-06 00:00:00
abstract:INTRODUCTION:The objective of this study was to evaluate the effects of two different mean arterial blood pressure (MAP) targets on needs for resuscitation, organ dysfunction, mitochondrial respiration and inflammatory response in a long-term model of fecal peritonitis. METHODS:Twenty-four anesthetized and mechanicall...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12495
更新日期:2013-01-30 00:00:00